Here’s How To Build Your Own Fat Loss Supplement Stack


Unsurprisingly, “fat-burners” is one of the most popular categories in the supplement industry, which shouldn’t come as a surprise since most people beginning a workout routine are generally looking to lose body fat, as well as to improve their body composition.

Before we give you a short list of some of the best supplements you should consider when building your own fat-loss stack, it’s paramount to keep in mind that no amount of supplements will ever do the work for you. That’s your job! Do you want to know what else they won’t do? They won’t make up for your poor dietary habits or lack of exercise, which means you’re still required to break a sweat.

Also, for efficiency, it is recommended that you get your nutrition and training regimen on track before you spend any money on fat-burning supplements. You have to learn how to smith before you buy a blacksmith hammer, don’t you?

Here are some of the most popular/effective fat-burning supplements.


Although you might think that caffeine exists with the sole purpose of keeping you awake during the day, caffeine is actually an alkaline, organic methylxanthine that is the foundation of many fat-burning stacks.

The ingestion of methylxanthines postpones the breakdown of cyclic adenosine monophosphate(cAMP) and cyclic guanosine monophosphate (cGMP) via inhibition of phosphodiesterase enzymes (PDE); therefore, caffeine is considered a PDE inhibitor. Since both cAMP and cGMP are crucial messengers in terms of cell signal transduction, your metabolic processes are sent into a serious overdrive after you ingest PDE inhibitors.

Research indicates that caffeine is capable of augmenting both aerobic and anaerobic exercise, as well as lowering the rate of perceived exertion (RPE). The point is that, after you take caffeine, you generally have an increased athletic performance capacity, which results in longer and harder workout sessions, thus leading to increased caloric and fat burning.


Yohimbine is a stimulant compound that derives from the plant species Pausinystalia Yohimbe. It’s an antagonist of alpha-2 adrenergic receptors and acts as a monoamine oxidase inhibitor. When taken pre-exercise, yohimbine enhances lipolytic activity by blocking alpha-2 adrenergic receptors in adipocytes and stimulating catecholamine release. It is also suggested that yohimbine provides the best results in the absence of insulin.

Similar to caffeine, you should monitor your intake so as not to overdo things. Like with many other supplements, yohimbine dosage will vary by body size and type – about 0.1-0.3mg/kg of body weight at a time is quite sufficient for fat loss.

It’s preferable to take yohimbine about 30 minutes pre-exercise on an empty stomach.


Capsaicinoids are the compounds that are found in peppers. They are responsible for giving them spice and heat. Literature suggests that capsaicin acts to increase metabolic expenditure. However, you can’t possibly expect to eat the amount of hot peppers needed to reach the nominal doses of capsaicinoids because you’d go through several gastric irritations and other digestive qualms on your way there. That’s why extracts exist, though.

Research supports claims that the mechanism for increased metabolic expenditure after capsaicin ingestion is based on beta-adrenergic stimulation. This increase in energy expenditure and the concomitant decrease in respiratory quotient can have a positive effect on fat oxidation.

The nominal dose ranges between 2-3mg at a time, up to three times per day. You might want to take capsaicin with meals since eating it on an empty stomach might cause all kinds of stomach problems for people who don’t tolerate spicy food that much.

Pyrroloquinoline quinone (PQQ)

PQQ is a natural compound that can be found in quinoproteins (which are often found in bacteria). It is primarily harvested from fermented soybeans. The most interesting thing about PQQ is that it is able to create new mitochondria in cells, which researchers often refer to as mitochondrial biogenesis.

PQQ basically acts as a cellular messenger, mimicking some of the most fundamental effects of exercise. Ultimately, it increases the body’s natural production of the hormone Irisin, which is considered one of the most important effects of physical activity, as levels of circulating Irisin drop rapidly with age.

Studies have shown that the consumption of PQQ at 20mg to 60mg per day is both effective and safe whereas the timing is not too important since its effects are latent and develop after continual use has been established.

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